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      FGF-9(C-6His)(10ug)

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      • 產品型號:abs04229
      • 廠商性質:生產廠家
      • 更新時間:2018-03-16
      • 訪  問  量:261

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      詳細介紹

      品牌自營品牌貨號abs04229
      規格10ug供貨周期一周
      概述
      描述Recombinant Mouse Fibroblast growth factor 9 is produced by our E.coli expression system and the target gene encoding Met1­Ser208 is expressed with a 6his tag at the C-terminus.
      別名Fibroblast growth factor 9;FGF-9;Glia-activating factor;GAF;heparin-binding growth factor-9;HBGF-9;Fgf9;Fgf-9
      形態Supplied as a 0.2 μm filtered solution of 20mM Tris,150mM NaCl,5%Trehalose,1mM EDTA,20%glycerol,1mM DTT,pH8.5 .
      來源E.coli
      氨基酸序列MHHHHHHMAPLGEVGSYFGVQDAVPFGNVPVLPVDSPVLLSDHLGQSEAGGLPRGPAVTDLDHLK GILRRRQLYCRTGFHLEIFPNGTIQGTRKDHSRFGILEFISIAVGLVSIRGVDSGLYLGMNEKGE LYGSEKLTQECVFREQFEENWYNTYSSNLYKHVDTGRRYYVALNKDGTPREGTRTKRHQKFTHFL PRPVDPDKVPELYKDILSQS*
      內毒素水平Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
      Accession #P54130
      性能
      背景Fibroblast growth factor-9 (FGF-9) is an approximay 26 kDa secreted glycoprotein of the FGF family. Secreted mouse FGF-9 lacks the N-terminal 1-3 aa and shares >98% sequence identity with rat, human, equine, porcine and bovine FGF-9. FGF-9 plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. In the mouse embryo the location and timing of FGF-9 expression affects development of the skeleton, cerebellum, lungs, heart, vasculature, digestive tract, and testes .It may have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors. Deletion of mouse FGF-9 is lethal at birth due to lung hypoplasia, and causes rhizomelia, or shortening of the proximal skeleton. An unusual constitutive dimerization of FGF 9 buries receptor interaction sites which lowers its activity, and increases heparin affinity which inhibits diffusion. A spontaneous mouse mutant, Eks, interferes with dimerization, resulting monomeric, diffusible FGF-9 that causes elbow and knee synostoses (joint fusions) due to FGF-9 misexpression in developing joints.
      保存方法Store at < -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
      純度Greater than 95% as determined by reducing SDS-PAGE.

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