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        首頁 > 產品中心 > 常規生化試劑 > CD抗原類重組蛋白 > abs04041PD-1/CD279 (C-6His)

        PD-1/CD279 (C-6His)

        簡要描述:愛必信特色產品線(全部現貨):
        二抗、標簽抗體、對照抗體;WB相關:ECL發光液、預染marker、預制膠;IHC相關:二抗試劑盒、組化筆;IP/CoIP試劑盒;細胞因子、信號通路調節劑;血清、BSA、蛋白酶K、CTB、TTX、CEE;凋亡試劑盒、呼吸爆發試劑盒;動植物提取物...

        • 產品型號:abs04041
        • 廠商性質:生產廠家
        • 更新時間:2018-03-22
        • 訪  問  量:318

        詳細介紹

        品牌自營品牌規格10ug
        供貨周期一周
        概述
        描述Recombinant Mouse Programmed Cell Death Protein 1 is produced by our Mammalian expression system and the target gene encoding Leu25-Gln167 is expressed with a 6His tag at the C-terminus.
        別名Programmed cell death protein 1,PD-1,CD279,Pdcd1,mPD-1
        形態Lyophilized from a 0.2 μm filtered solution of 20mM Tris,150mM NaCl,pH8.0.
        來源Human Cells
        氨基酸序列LEVPNGPWRSLTFYPAWLTVSEGANATFTCSLSNWSEDLMLNWNRLSPSNQTEKQAAFCNGLSQP VQDARFQIIQLPNRHDFHMNILDTRRNDSGIYLCGAISLHPKAKIEESPGAELVVTERILETSTR YPSPSPKPEGRFQVDHHHHHH
        內毒素水平Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test.
        Accession #Q02242
        性能
        背景Programmed Death-1 (PD-1), firstly cloned from mouse T cell hybridoma 2B4.11, is one member of CD28/CTLA-4 superfamily. PD-1 belongs to type I transmembrane protein and acts as an important immunosuppressive molecule. The cytoplamsic tail of PD-1 contains two structural motifs, an immunoreceptor tyrosine-based inhibitory motif (ITIM) and an immunoreceptor tyrosine-based switch motif (ITSM) formed by two tyrosine residues which make the difference in PD-1 signal mediating. Mouse PD-1 is expressed in thymus and shares about 69% aa sequence identity with human PD-1. Recently, programmed death-1 (PD-1) with its ligands, programmed death ligand B7H1 (PD-L1) and B7DC (PD-L2), was found to regulate T-cell activation and tolerance, upon ligand binding, inhibiting T-cell effector functions in an antigen-specific manner. PD-1 gene knocked out mice would induce some autoimmune diseases, which suggests that PD-1 acts as a co-inhibitory molecule actively participating in maintaining peripheral tolerance. Thus, PD-1 may be a useful target for the immunologic therapy of carcinoma,infection,autoimmune diseases as well as organ transplantation.
        溶解方法Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
        保存方法Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
        純度Greater than 95% as determined by reducing SDS-PAGE.

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